If this fails, many surgical treatments are available according to the stage of the condition.. Adult onset flatfoot: a guide to posterior tibial tendon dysfunction A common reason behind adult onset flatfoot deformity is dysfunction of the posterior tibial tendon. Early recognition of the dysfunction is important due to the progressive nature. Non-operative and operative treatment plans depend on the severity of the symptoms and the stage of the disease. The diagnosis of posterior tibial tendon dysfunction is founded on a thorough background, study of the foot and simple radiographs.Thus, the study does not allow a very clear identification of an age threshold beyond which the usage of ritonavir-boosted lopinavir could be avoided. We think that the analysis provides strong proof that ritonavir-boosted lopinavir should be used as the initial therapy in children more youthful than 12 months old who have had prior exposure to single-dosage nevirapine, with moderate evidence that this recommendation should be extended to kids 12 to thirty six months of age. Analyses of baseline NNRTI resistance showed that children with detectable mutations associated with resistance to nevirapine, as assessed by people sequencing, were at high risk for too little response to nevirapine treatment.